Hermosillo is one of the most successful Mexican directors of the last twenty years. Born in Aguascalientes, a small city in central Mexico, Hermosillo's films have dissected the hypocrisy of Mexican middle class and "torn the curtain" behind which many perversities are hidden. He has become an important figure in Mexican contemporary cinema and is known for treating themes of sexual diversity from a personal approach. One of the few openly gay Mexican directors, Hermosillo found a great success with Doña Herlinda y su hijo (1985), a comedy about a mother of a gay doctor who manipulates her son, his male lover and his fiancée to fulfill her desire of becoming a grandmother. Homosexual themes in Hermosillo's films can be found in Matinee, El Cumpleaños del Perro, and Las apariencias engañan (1978). Hermosillo has also been a explorer of film language. La Tarea is one of the most complex exercises in film style in recent years (the film consists of one long shot, from the POV of a camcorder). Hermosillo's films presents a fresh look on Mexican society. A strong advocate of digital cinema, he has made ten feature films in this format.
His favorite director is 乔治·库克
Before 佩德罗·阿莫多瓦 (with whom he is frequently compared) Hermosillo gave his own mother the chance of acting in his movies. She (María Guadalupe Delgado) even has a leading role in _Nuestros, Los (1969)_